Abraham J. Cisneros Mejorado, CONAHCYT Researcher
Institute of Neurobiology, UNAM
Cellular Neurophysiology Lab. (D-14)
CONAHCYT Researcher
Currently, together with the great work team at theLab. D1-4 of the INB, we are interested in researching the communication between neurons and the oligodendroglial lineage, mainly to better understand how the myelination process takes place in the brain. Furthermore, using various experimental strategies, we constantly evaluate the possibility of modulating this phenomenon in scenarios where there has been damage to myelin at different stages..
To carry out our work, some of the methodologies we use are cross-sectional, such as histology, while we do longitudinal monitoring through magnetic resonance.
To a large extent our experimental approaches are carried out making use of animal models.
local demyelination
Through a localized injection, we can place substances that alter myelin in a region of the brain. When myelin is lost, this is a phenomenon of demyelination and occurs in almost all (if not all) neurodegenerative diseases.
Multiple Sclerosis Model
Multiple Sclerosis (MS) is a disease that affects significantly worldwide, it is a demyelinating pathology.
In the Laboratory, we inquire about demyelination, but above all remyelination (myelin repair) in a model of demyelination induced by a compound called cuprizone, a model that is similar in various aspects to MS.
OLs evaluation
The cells responsible for the formation of myelin are oligodendrocytes (OLs), and part of our task is to identify and characterize the molecules that act on OLs and evaluate the possibility of modulating these cells in their main function, myelination.